Postsynaptic scaffold protein Homer 1a protects against traumatic brain injury via regulating group I metabotropic glutamate receptors
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منابع مشابه
Metabotropic glutamate receptors trigger postsynaptic protein synthesis.
K+ depolarization or addition of glutamate to a synaptoneurosome preparation triggers a rapid increase in size of polyribosomal aggregates isolated by centrifugation of lysate through 1 M sucrose. The profile of response to the glutamate analogues quisqualate, ibotenate, and 1-aminocyclopentane-1,3-dicarboxylate corresponds to that of metabotropic receptors. Glutamate stimulation is mimicked by...
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Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrPC is required for toxicity, suggesting the existence of deleterious PrPC-dependent signaling cascades. Because group-I metabotropic glutamate receptors (mGluR1 and mGluR5) can form complexes with the cellular prion protein (PrPC), we investigated the impact ...
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A reduction in microglial activation and subsequent neurotoxicity may prove critical for neuroprotection in neurodegenerative diseases. We examined the expression and functionality of group III metabotropic glutamate (mGlu) receptors on microglia. Rat microglia express mRNA and receptor protein for group III mGlu receptors mGlu4, mGlu6, and mGlu8 but not mGlu7. Activation of these receptors on ...
متن کاملGroup I Metabotropic Glutamate Receptors (mGlu1 and mGlu5)
The metabotropic glutamate (mGlu) receptors are a family of eight G protein-coupled receptors that modulate cell excitability and synaptic transmission in the nervous system. Group I mGlu receptors are generally coupled to Gq stimulation of phospholipase C and the release of intracellular calcium. The physiologic effects of group I mGlu receptors in the brain are diverse and highlight the impor...
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A discriminating pharmacophore model for noncompetitive metabotropic glutamate receptor antagonists of subtype 1 (mGluR1) was developed that facilitated the discovery of moderately active mGluR1 antagonists. One scaffold was selected for the design of several focused libraries where different substitution patterns were introduced. This approach facilitated the discovery of potent mGluR1 antagon...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2014
ISSN: 2041-4889
DOI: 10.1038/cddis.2014.116